Endocrine Abstracts

Objective: The aim of the study was to compare the clinical features in three age-groups of women with primary hyperparathyroidism.Methods: The data about biochemical profile and disease complications in women with active stage of disease (n=645) was collected from the Russian Primary Hyperparathyroidism Registry. Group 1 included women 20–49 years old (n=215) unless the patients with suspected or confirmed multiple endocrine neopl...

Background: Secondary hyperparathyroidism (SHPT) is severe complication of chronic kidney disease, characterized by high serum parathyroid hormone (PTH), parathyroid gland hyperplasia, and disturbances in mineral metabolism. Effective management of SHPT includes measures to prevent hyperphosphataemia and excess PTH, to maintain serum calcium within the normal range. In dialysis patients with severe SHPT, medical treatment may fail and parathyroidectomy (PTX) is indicated for d...

Background: In type 1 diabetes (T1D), optimal glycaemic control requires intensive self-management to reduce the risk of complications. While routine downloading and review of blood glucose data is part of clinical practice of healthcare providers in an outpatient setting, patients and families are also educated, advised and encouraged to regularly download and review blood glucose data at home in order to make adjustments to insulin dosing for carbohydrate intake and insulin ...

Introduction: It is essential that children and young people with diabetes are supported to manage their diabetes effectively to prevent the development of early complications. However, the common clinical challenge is difficultly in engaging adolescents and young people to achieve good glycaemic control in their diabetes management. Solution Focus Therapy (SFBT) has been found to be especially beneficial with children, adolescents and teenagers because it is a brief model tra...

Self-monitoring of blood glucose (SMBG) is an important part of diabetes management. Continuous glucose monitoring (CGM) provides real-time measurement of users’ glucose levels. The advantage of CGM is the availability of constant information about glucose levels which helps to predict hyper and hypoglycaemia and to adjust the insulin doses accordingly. NICE guidelines recommend that children and young people with type 1 diabetes and persistent problems with hypoglycaemia...

Background: Previous studies have reported that increased BMI and increase in insulin requirement are associated with more rapid disease progression following diagnosis in type 1 diabetes mellitus (T1DM). The recent UK National Paediatric Diabetes Audit (NPDA) 2013/14 reported that 37% of 0–11 year old children and 44% of 12 years and older children are currently overweight or obese.Objective: Our objective was to evaluate factors associated with in...

Background: Isolated prepubertal vaginal bleeding can be secondary to various causes including Mullerian cyst, papilloma, foreign body and prepubertal menarche. There is no current consensus on the investigations for prepubertal girls with isolated vaginal bleeding with no other signs of precocious puberty.Objective: The objective of our study is to evaluate the factors associated with persistent isolated cyclical vaginal bleeding including clinical pres...

Aim: To study the effect of type 1 diabetes mellitus (T1DM) and concurrent autoimmune condition (AI) on long term glycemic control and growth in children.Methods: Twenty-eight children with T1DM and associated autoimmune condition were matched by sex and age at onset with two controls each. HbA1C, height SDS, weight SDS and BMI SDS were measured between 6 months and 5 years after developing T1DM.Results: We included 28 children wit...

Introduction: T1DM is an autoimmune condition. At diagnosis, 80% of patients have positive glutamic-acid decarboxylase antibodies (GADA). We report a case of T1DM diagnosed 1 year after the onset of autoimmune limbic encephalitis (LE).Case: A 13-year-old female was diagnosed with voltage-gated-potassium channel (VGKC) positive LE after presenting with complex partial seizures and auditory hallucinations. A year later and prior to the diagnosis of diabete...

Introduction: The short synacthen test (SST) is commonly used to assess the hypothalamic pituitary adrenal (HPA) axis in clinical practice. We evaluated the underlying clinical conditions pre-empting the request for a SST in a general medical ward and the adequacy of clinical follow up of patients with suboptimal responses to the test.Methods: All patients with suboptimal SST results (30 min cortisol level 450–540 nmol/l) performed in the Acute Asse...